FXYD3 tissues
FXYD3 [ENSP00000473929]
FXYD domain-containing ion transport regulator 3; Associates with and regulates the activity of the sodium/potassium-transporting ATPase (NKA) which transports Na(+) out of the cell and K(+) into the cell . Reduces glutathionylation of the NKA beta-1 subunit ATP1B1, thus reversing glutathionylation-mediated inhibition of ATP1B1 . Induces a hyperpolarization-activated chloride current when expressed in Xenopus oocytes . [Isoform 2]: Decreases the apparent K+ affinity of the sodium/potassium-transporting ATPase only at slightly negative and positive membrane potentials and increases the apparent Na+ affinity over a large range of membrane potentials. ; Belongs to the FXYD family.
Synonyms: FXYD3, FXYD3p, hFXYD3, Q14802, S4R3M2 ...