TISSUES

Tissue expression database

GSKIP tissues

GSKIP [ENSP00000451188]

GSK3B-interacting protein; A-kinase anchoring protein for GSK3B and PKA that regulates or facilitates their kinase activity towards their targets . The ternary complex enhances Wnt-induced signaling by facilitating the GSK3B- and PKA-induced phosphorylation of beta-catenin leading to beta-catenin degradation and stabilization respectively (PubMed:27484798, PubMed:16981698). Upon cAMP activation, the ternary complex contributes to neuroprotection against oxidative stress-induced apoptosis by facilitating the PKA-induced phosphorylation of DML1 and PKA-induced inactivation of GSK3B . During neurite outgrowth promotes neuron proliferation; while increases beta-catenin-induced transcriptional activity through GSK3B kinase activity inhibition, reduces N-cadherin level to promote cell cycle progression . ECO:0000269|PubMed:19830702, ECO:0000269|PubMed:25920809,

Synonyms:  GSKIP,  A0A024R6P6,  C14orf129,  G3V368,  G3V4I5 ...

Linkouts:  STRING  Pharos  UniProt

0 1 2 3 4 5 Confidence