TISSUES

Tissue expression database

JensenLab

CMKLR1 tissues

CMKLR1 [ENSP00000449716]

Chemokine-like receptor 1; Receptor for the chemoattractant adipokine chemerin/RARRES2 and for the omega-3 fatty acid derived molecule resolvin E1. Interaction with RARRES2 induces activation of intracellular signaling molecules, such as SKY, MAPK1/3 (ERK1/2), MAPK14/P38MAPK and PI3K leading to multifunctional effects, like, reduction of immune responses, enhancing of adipogenesis and angionesis. Resolvin E1 down- regulates cytokine production in macrophages by reducing the activation of MAPK1/3 (ERK1/2) and NF-kappa-B. Positively regulates adipogenesis and adipocyte metabolism. Acts as a coreceptor for several SIV strains (SIVMAC316, SIVMAC239, SIVMACL7E-FR and SIVSM62A), as well as a primary HIV-1 strain (92UG024-2). ECO:0000269|PubMed:15753205, ECO:0000269|PubMed:20044979,

Synonyms:  CMKLR1,  CMKLR1p,  hCMKLR1,  F8VSC8,  F8VYN7 ...

Linkouts:  STRING  Pharos  UniProt

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