TISSUES

Tissue expression database

GGA3 tissues

GGA3 [ENSP00000438085]

ADP-ribosylation factor-binding protein GGA3; Plays a role in protein sorting and trafficking between the trans-Golgi network (TGN) and endosomes. Mediates the ARF-dependent recruitment of clathrin to the TGN and binds ubiquitinated proteins and membrane cargo molecules with a cytosolic acidic cluster-dileucine (DXXLL) motif . Mediates export of the GPCR receptor ADRA2B to the cell surface . nvolved in BACE1 transport and sorting as well as regulation of BACE1 protein levels . Regulates retrograde transport of BACE1 from endosomes to the trans-Golgi network via interaction through the VHS motif and dependent of BACE1 phosphorylation . Modulates BACE1 protein levels intedepently of the interaction between VHS domain and DXXLL motif through recognition of ubiquitination . Key player in a novel DXXLL-mediated endosomal sorting machinery to the recycling pathway that targets NTRK1 to the plasma membrane (By similarity). ECO:0000269|PubMed:15615712, ECO:0000269|PubMed:17553422,

Synonyms:  GGA3,  GGA3p,  hGGA3,  A0A087WYN2,  B7Z1E9 ...

Linkouts:  STRING  Pharos  UniProt

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