SDCBP tissues
SDCBP [ENSP00000428184]
Syntenin-1; Multifunctional adapter protein involved in diverse array of functions including trafficking of transmembrane proteins, neuro and immunomodulation, exosome biogenesis, and tumorigenesis . Positively regulates TGFB1-mediated SMAD2/3 activation and TGFB1-induced epithelial-to-mesenchymal transition (EMT) and cell migration in various cell types. May increase TGFB1 signaling by enhancing cell-surface expression of TGFR1 by preventing the interaction between TGFR1 and CAV1 and subsequent CAV1-dependent internalization and degradation of TGFR1 . In concert with SDC1/4 and PDCD6IP, regulates exosome biogenesis . Regulates migration, growth, proliferation, and cell cycle progression in a variety of cancer types . In adherens junctions may function to couple syndecans to cytoskeletal proteins or signaling components. Seems to couple transcription factor SOX4 to the IL-5 receptor (IL5RA) . May also play a role in vesicular trafficking . Seems to be required for the targeting of TGFA to the cell surface in the early secretory pathway . ECO:0000269|PubMed:11179419, ECO:0000269|PubMed:11498591, ECO:0000269|PubMed:22660413, ECO:0000269|PubMed:25893292,
Synonyms: SDCBP, A0A024R7Z5, B4DHN5, E9PBU7, G5EA09 ...