TISSUES

Tissue expression database

AMOTL2 tissues

AMOTL2 [ENSP00000424765]

Angiomotin-like protein 2; Regulates the translocation of phosphorylated SRC to peripheral cell-matrix adhesion sites. Required for proper architecture of actin filaments. Inhibits the Wnt/beta-catenin signaling pathway, probably by recruiting CTNNB1 to recycling endosomes and hence preventing its translocation to the nucleus. Participates in angiogenesis. May play a role in the polarity, proliferation and migration of endothelial cells. Selectively promotes FGF-induced MAPK activation through SRC; Belongs to the angiomotin family.

Synonyms:  AMOTL2,  AMOTL2p,  hAMOTL2,  D6RBK2,  D6RCL7 ...

Linkouts:  STRING  Pharos  UniProt

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