FXN tissues
FXN [ENSP00000419243]
Frataxin intermediate form; Promotes the biosynthesis of heme and assembly and repair of iron-sulfur clusters by delivering Fe(2+) to proteins involved in these pathways. May play a role in the protection against iron-catalyzed oxidative stress through its ability to catalyze the oxidation of Fe(2+) to Fe(3+); the oligomeric form but not the monomeric form has in vitro ferroxidase activity. May be able to store large amounts of iron in the form of a ferrihydrite mineral by oligomerization; however, the physiological relevance is unsure as reports are conflicting and the function has only been shown using heterologous overexpression systems. Modulates the RNA-binding activity of ACO1. ECO:0000269|PubMed:15641778, ECO:0000269|PubMed:16239244,; Belongs to the frataxin family.
Synonyms: FXN, A0A0S2Z3G4, A0A0S2Z3Q8, C9JAX1, H7C585 ...