TRA2B tissues
TRA2B [ENSP00000416959]
Transformer-2 protein homolog beta; Sequence-specific RNA-binding protein which participates in the control of pre-mRNA splicing. Can either activate or suppress exon inclusion. Acts additively with RBMX to promote exon 7 inclusion of the survival motor neuron SMN2. Activates the splicing of MAPT/Tau exon 10. Alters pre-mRNA splicing patterns by antagonizing the effects of splicing regulators, like RBMX. Binds to the AG-rich SE2 domain in the SMN exon 7 RNA. Binds to pre-mRNA. ECO:0000269|PubMed:12761049, ECO:0000269|PubMed:15009664,; Belongs to the splicing factor SR family.
Synonyms: TRA2B, TRA2Bp, hTRA2B, H7BXF3, H7C2L4 ...