TISSUES

Tissue expression database

JensenLab

TRIB3 tissues

TRIB3 [ENSP00000415416]

Tribbles homolog 3; Disrupts insulin signaling by binding directly to Akt kinases and blocking their activation. May bind directly to and mask the 'Thr- 308' phosphorylation site in AKT1. Binds to ATF4 and inhibits its transcriptional activation activity. Interacts with the NF-kappa-B transactivator p65 RELA and inhibits its phosphorylation and thus its transcriptional activation activity. Interacts with MAPK kinases and regulates activation of MAP kinases. May play a role in programmed neuronal cell death but does not appear to affect non-neuronal cells. Does not display kinase activity. Inhibits the transcriptional activity of DDIT3/CHOP and is involved in DDIT3/CHOP-dependent cell death during ER stress. Can inhibit APOBEC3A editing of nuclear DNA. ECO:0000269|PubMed:15775988, ECO:0000269|PubMed:15781252,

Synonyms:  TRIB3,  TRIB3p,  hTRIB3,  A0A087WTX3,  B0QYQ2 ...

Linkouts:  STRING  Pharos  UniProt

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