TISSUES

Tissue expression database

CELF4 tissues

CELF4 [ENSP00000410584]

CUGBP Elav-like family member 4; RNA-binding protein implicated in the regulation of pre-mRNA alternative splicing. Mediates exon inclusion and/or exclusion in pre- mRNA that are subject to tissue-specific and developmentally regulated alternative splicing. Specifically activates exon 5 inclusion of cardiac isoforms of TNNT2 during heart remodeling at the juvenile to adult transition. Promotes exclusion of both the smooth muscle (SM) and non-muscle (NM) exons in actinin pre-mRNAs. Activates the splicing of MAPT/Tau exon 10. Binds to muscle-specific splicing enhancer (MSE) intronic sites flanking the alternative exon 5 of TNNT2 pre-mRNA. ECO:0000269|PubMed:14973222, ECO:0000269|PubMed:15009664,; Belongs to the CELF/BRUNOL family.

Synonyms:  CELF4,  CELF4p,  hCELF4,  A0A0A0MTT3,  A0A0C4DGR1 ...

Linkouts:  STRING  Pharos  UniProt

0 1 2 3 4 5 Confidence