TISSUES

Tissue expression database

SUMO2 tissues

SUMO2 [ENSP00000405965]

Small ubiquitin-related modifier 2; Ubiquitin-like protein that can be covalently attached to proteins as a monomer or as a lysine-linked polymer. Covalent attachment via an isopeptide bond to its substrates requires prior activation by the E1 complex SAE1-SAE2 and linkage to the E2 enzyme UBE2I, and can be promoted by an E3 ligase such as PIAS1-4, RANBP2, CBX4 or ZNF451 . This post-translational modification on lysine residues of proteins plays a crucial role in a number of cellular processes such as nuclear transport, DNA replication and repair, mitosis and signal transduction. Polymeric SUMO2 chains are also susceptible to polyubiquitination which functions as a signal for proteasomal degradation of modified proteins (PubMed:18408734, PubMed:18538659, PubMed:21965678, PubMed:9556629). Plays a role in the regulation of sumoylation status of SETX . ECO:0000269|PubMed:21965678, ECO:0000269|PubMed:24105744,

Synonyms:  SUMO2,  SUMO2p,  hSUMO2,  A0A024R8S3,  J3KRH1 ...

Linkouts:  STRING  Pharos  UniProt  OMIM

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