TISSUES

Tissue expression database

RANBP1 tissues

RANBP1 [ENSP00000401564]

Ran-specific GTPase-activating protein; Plays a role in RAN-dependent nucleocytoplasmic transport. Alleviates the TNPO1-dependent inhibition of RAN GTPase activity and mediates the dissociation of RAN from proteins involved in transport into the nucleus (By similarity). Induces a conformation change in the complex formed by XPO1 and RAN that triggers the release of the nuclear export signal of cargo proteins . Promotes the disassembly of the complex formed by RAN and importin beta. Promotes dissociation of RAN from a complex with KPNA2 and CSE1L (By similarity). Required for normal mitotic spindle assembly and normal progress through mitosis via its effect on RAN . Does not increase the RAN GTPase activity by itself, but increases GTP hydrolysis mediated by RANGAP1 . Inhibits RCC1- dependent exchange of RAN-bound GDP by GTP (PubMed:7882974, PubMed:7616957). ECO:0000269|PubMed:17671426, ECO:0000269|PubMed:20485264,

Synonyms:  RANBP1,  RANBP1p,  hRANBP1,  A0A140VK94,  C9JDM3 ...

Linkouts:  STRING  Pharos  UniProt

0 1 2 3 4 5 Confidence