TISSUES

Tissue expression database

JensenLab

CD14 tissues

CD14 [ENSP00000385519]

Monocyte differentiation antigen CD14, membrane-bound form; Coreceptor for bacterial lipopolysaccharide (PubMed:1698311, PubMed:23264655). In concert with LBP, binds to monomeric lipopolysaccharide and delivers it to the LY96/TLR4 complex, thereby mediating the innate immune response to bacterial lipopolysaccharide (LPS) . Acts via MyD88, TIRAP and TRAF6, leading to NF-kappa-B activation, cytokine secretion and the inflammatory response . Acts as a coreceptor for TLR2:TLR6 heterodimer in response to diacylated lipopeptides and for TLR2:TLR1 heterodimer in response to triacylated lipopeptides, these clusters trigger signaling from the cell surface and subsequently are targeted to the Golgi in a lipid-raft dependent pathway . Binds electronegative LDL (LDL(-)) and mediates the cytokine release induced by LDL(-) . ECO:0000269|PubMed:20133493, ECO:0000269|PubMed:23264655,

Synonyms:  CD14,  CD14p,  hCD14,  D6RD81,  D6RFL4 ...

Linkouts:  STRING  Pharos  UniProt

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