HYPK tissues
HYPK [ENSP00000384474]
Huntingtin-interacting protein K; Has a chaperone-like activity preventing polyglutamine (polyQ) aggregation of HTT . Protects against HTT polyQ-mediated apoptosis in Neuro2a neuronal cells . Regulator of the N-terminal acetyltransferase NAA10-NAA15 complex . Has been in one study shown to be required for optimal NAA10-NAA15 complex-mediated N-terminal acetylation . However, has been shown in another study to act in vitro as an inhibitor of NAA10-NAA15 complex-mediated N- terminal acetylation .
Synonyms: HYPK, A0A024R5Q1, J3QT56, Q9NX55, J3QT56p ...