TISSUES

Tissue expression database

ABCC1 tissues

ABCC1 [ENSP00000382342]

Multidrug resistance-associated protein 1; Mediates export of organic anions and drugs from the cytoplasm (PubMed:7961706, PubMed:16230346, PubMed:9281595, PubMed:10064732, PubMed:11114332). Mediates ATP-dependent transport of glutathione and glutathione conjugates, leukotriene C4, estradiol-17- beta-o-glucuronide, methotrexate, antiviral drugs and other xenobiotics (PubMed:7961706, PubMed:16230346, PubMed:9281595, PubMed:10064732, PubMed:11114332). Confers resistance to anticancer drugs by decreasing accumulation of drug in cells, and by mediating ATP- and GSH-dependent drug export . Hydrolyzes ATP with low efficiency . Catalyzes the export of sphingosine 1-phosphate from mast cells independently of their degranulation . Participates in inflammatory response by allowing export of leukotriene C4 from leukotriene C4-synthezing cells (By similarity). ECO:0000269|PubMed:11114332, ECO:0000269|PubMed:16230346, ECO:0000269|PubMed:17050692, ECO:0000269|PubMed:7961706,

Synonyms:  ABCC1,  ABCC1p,  hABCC1,  A0A0A0MS99,  I3L2H9 ...

Linkouts:  STRING  Pharos  UniProt  OMIM

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