TISSUES

Tissue expression database

NLRP12 tissues

NLRP12 [ENSP00000375653]

NACHT, LRR and PYD domains-containing protein 12; Plays an essential role as an potent mitigator of inflammation . Primarily expressed in dendritic cells and macrophages, inhibits both canonical and non-canonical NF-kappa-B and ERK activation pathways . Functions as a negative regulator of NOD2 by targeting it to degradation via the proteasome pathway . In turn, promotes bacterial tolerance . Inhibits also the DDX58-mediated immune signaling against RNA viruses by reducing the E3 ubiquitin ligase TRIM25-mediated 'Lys-63'-linked DDX58 activation but enhancing the E3 ubiquitin ligase RNF125-mediated 'Lys-48'-linked DDX58 degradation . Acts also as a negative regulator of inflammatory response to mitigate obesity and obesity-associated diseases in adipose tissue (By similarity). ECO:0000269|PubMed:17947705, ECO:0000269|PubMed:30559449,

Synonyms:  NLRP12,  NLRP12p,  hNLRP12,  A0A0C4DFY3,  A0A0C4DH17 ...

Linkouts:  STRING  Pharos  UniProt

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