TISSUES

Tissue expression database

HMGCL tissues

HMGCL [ENSP00000363614]

Hydroxymethylglutaryl-CoA lyase, mitochondrial; Mitochondrial 3-hydroxymethyl-3-methylglutaryl-CoA lyase that catalyzes a cation-dependent cleavage of (S)-3-hydroxy-3- methylglutaryl-CoA into acetyl-CoA and acetoacetate, a key step in ketogenesis. Terminal step in leucine catabolism. Ketone bodies (beta- hydroxybutyrate, acetoacetate and acetone) are essential as an alternative source of energy to glucose, as lipid precursors and as regulators of metabolism.

Synonyms:  HMGCL,  H0Y2L7,  P35914,  H0Y2L7p,  hH0Y2L7 ...

Linkouts:  STRING  Pharos  UniProt  OMIM

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