TISSUES

Tissue expression database

CYP2J2 tissues

CYP2J2 [ENSP00000360247]

Cytochrome P450 2J2; A cytochrome P450 monooxygenase involved in the metabolism of polyunsaturated fatty acids (PUFA) in the cardiovascular system . Mechanistically, uses molecular oxygen inserting one oxygen atom into a substrate, and reducing the second into a water molecule, with two electrons provided by NADPH via cytochrome P450 reductase (NADPH--hemoprotein reductase) . Catalyzes the epoxidation of double bonds of PUFA . Converts arachidonic acid to four regioisomeric epoxyeicosatrienoic acids (EpETrE), likely playing a major role in the epoxidation of endogenous cardiac arachidonic acid pools . In endothelial cells, participates in eicosanoids metabolism by converting hydroperoxide species into hydroxy epoxy metabolites. In combination with 15- lipoxygenase metabolizes arachidonic acid and converts hydroperoxyicosatetraenoates (HpETEs) into hydroxy epoxy eicosatrienoates (HEETs), which are precursors of vasodilatory trihydroxyicosatrienoic acids (THETAs). This hydroperoxide isomerase activity is NADPH- and O2-independent . Catalyzes the monooxygenation of a various xenobiotics, such as danazol, amiodarone, terfenadine, astemizole, thioridazine, tamoxifen, cyclosporin A and nabumetone . Catalyzes hydroxylation of the anthelmintics albendazole and fenbendazole . Catalyzes the sulfoxidation of fenbedazole . ECO:0000269|PubMed:19965576, ECO:0000269|PubMed:23959307,

Synonyms:  CYP2J2,  CYP2J2p,  hCYP2J2,  A0A3B3IT99,  A0A3B3ITF2 ...

Linkouts:  STRING  Pharos  UniProt  OMIM

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