IER5 tissues
IER5 [ENSP00000356549]
Immediate early response gene 5 protein; Plays a role as a transcription factor (PubMed:22132193, PubMed:25355627). Mediates positive transcriptional regulation of several chaperone genes during the heat shock response in a HSF1- dependent manner . Mediates negative transcriptional regulation of CDC25B expression . Plays a role in the dephosphorylation of the heat shock factor HSF1 and ribosomal protein S6 kinase (S6K) by the protein phosphatase PP2A . Involved in the regulation of cell proliferation and resistance to thermal stress (PubMed:22132193, PubMed:25355627, PubMed:26496226). Involved in the cell cycle checkpoint and survival in response to ionizing radiation . Associates with chromatin to the CDC25B promoter . ECO:0000269|PubMed:22132193, ECO:0000269|PubMed:25355627,; Belongs to the IER family.
Synonyms: IER5, IER5p, hIER5, Q5VY09, Q5VY09p ...