TISSUES

Tissue expression database

NR5A2 tissues

NR5A2 [ENSP00000356331]

Nuclear receptor subfamily 5 group A member 2; Nuclear receptor that acts as a key metabolic sensor by regulating the expression of genes involved in bile acid synthesis, cholesterol homeostasis and triglyceride synthesis. Together with the oxysterol receptors NR1H3/LXR-alpha and NR1H2/LXR-beta, acts as an essential transcriptional regulator of lipid metabolism. Plays an anti- inflammatory role during the hepatic acute phase response by acting as a corepressor: inhibits the hepatic acute phase response by preventing dissociation of the N-Cor corepressor complex . Binds to the sequence element 5'-AACGACCGACCTTGAG-3' of the enhancer II of hepatitis B virus genes, a critical cis-element of their expression and regulation. May be responsible for the liver-specific activity of enhancer II, probably in combination with other hepatocyte transcription factors. Key regulator of cholesterol 7-alpha-hydroxylase gene (CYP7A) expression in liver. May also contribute to the regulation of pancreas-specific genes and play important roles in embryonic development. Activates the transcription of CYP2C38 (By similarity). ECO:0000269|PubMed:15723037, ECO:0000269|PubMed:15897460,; Belongs to the nuclear hormone receptor family. NR5 subfamily.

Synonyms:  NR5A2,  NR5A2p,  hNR5A2,  E9PQH2,  F1D8R9 ...

Linkouts:  STRING  Pharos  UniProt  OMIM

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