TISSUES

Tissue expression database

JensenLab
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COL18A1 tissues

COL18A1 [ENSP00000352798]

Collagen alpha-1(XVIII) chain; Probably plays a major role in determining the retinal structure as well as in the closure of the neural tube. Endostatin: Potently inhibits endothelial cell proliferation and angiogenesis . May inhibit angiogenesis by binding to the heparan sulfate proteoglycans involved in growth factor signaling (By similarity). Inhibits VEGFA-induced endothelial cell proliferation and migration. Seems to inhibit VEGFA-mediated signaling by blocking the interaction of VEGFA to its receptor KDR/VEGFR2. Modulates endothelial cell migration in an integrin-dependent manner implicating integrin ITGA5:ITGB1 and to a lesser extent ITGAV:ITGB3 and ITGAV:ITGB5 (By similarity). May negatively regulate the activity of homotrimeric non-collagenous domain 1 .

Synonyms:  COL18A1,  COL18A1p,  hCOL18A1,  H7BXV5,  H7C457 ...

Linkouts:  STRING  Pharos  UniProt

0 1 2 3 4 5 Confidence

The tissue associations are derived from manually curated knowledge in UniProtKB and via automatic text mining of the biomedical literature, which has not been manually verified. The confidence of each association is signified by stars, where ★★★★★ is the highest confidence and ★☆☆☆☆ is the lowest. Download files from earlier versions are archived on figshare.

Each tissue–gene association is based on a text-mining score, which is proportional to 1) the absolute number of comentionings and 2) the ratio of observed to expected comentionings (i.e. the enrichment). These scores are normalized to z-scores by comparing them to a random background. This is represented by stars, each star corresponding to two standard deviations above the mean of the background distribution.

Developed by Alberto Santos, Oana Palasca, Christian Stolte, Kalliopi Tsafou, Sune Frankild, Janos Binder, Sean O'Donoghue, Jan Gorodkin, and Lars Juhl Jensen from the Novo Nordisk Foundation Center for Protein Research, Center for non-coding RNA in Technology and Health, and the Commonwealth Scientific and Industrial Research Organisation (CSIRO).

Currently maintained by Qingyao Huang at Swiss Institute of Bioinformatics, University of Zurich. Licensed under CC BY 4.0.