TISSUES

Tissue expression database

RANBP3 tissues

RANBP3 [ENSP00000341483]

Ran-binding protein 3; Acts as a cofactor for XPO1/CRM1-mediated nuclear export, perhaps as export complex scaffolding protein. Bound to XPO1/CRM1, stabilizes the XPO1/CRM1-cargo interaction. In the absence of Ran-bound GTP prevents binding of XPO1/CRM1 to the nuclear pore complex. Binds to CHC1/RCC1 and increases the guanine nucleotide exchange activity of CHC1/RCC1. Recruits XPO1/CRM1 to CHC1/RCC1 in a Ran-dependent manner. Negative regulator of TGF-beta signaling through interaction with the R-SMAD proteins, SMAD2 and SMAD3, and mediating their nuclear export. ECO:0000269|PubMed:11932251, ECO:0000269|PubMed:19289081,

Synonyms:  RANBP3,  RANBP3p,  hRANBP3,  B7Z7F3,  K7EID7 ...

Linkouts:  STRING  Pharos  UniProt  OMIM

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