DYRK1A tissues
DYRK1A [ENSP00000340373]
Dual specificity tyrosine-phosphorylation-regulated kinase 1A; Dual-specificity kinase which possesses both serine/threonine and tyrosine kinase activities. May play a role in a signaling pathway regulating nuclear functions of cell proliferation. Modulates alternative splicing by phosphorylating the splice factor SRSF6 (By similarity). Exhibits a substrate preference for proline at position P+1 and arginine at position P-3. Has pro-survival function and negatively regulates the apoptotic process. Promotes cell survival upon genotoxic stress through phosphorylation of SIRT1. This in turn inhibits TP53 activity and apoptosis (By similarity). ECO:0000269|PubMed:20981014, ECO:0000269|PubMed:21127067,
Synonyms: DYRK1A, DYRK1Ap, hDYRK1A, A0A2R8Y443, A0A2R8Y6I6 ...