TISSUES

Tissue expression database

ACSL4 tissues

ACSL4 [ENSP00000339787]

Long-chain-fatty-acid--CoA ligase 4; Catalyzes the conversion of long-chain fatty acids to their active form acyl-CoA for both synthesis of cellular lipids, and degradation via beta-oxidation (PubMed:24269233, PubMed:22633490, PubMed:21242590). Preferentially activates arachidonate and eicosapentaenoate as substrates . Preferentially activates 8,9-EET > 14,15-EET > 5,6-EET > 11,12-EET. Modulates glucose- stimulated insulin secretion by regulating the levels of unesterified EETs (By similarity). Modulates prostaglandin E2 secretion . ECO:0000269|PubMed:21242590, ECO:0000269|PubMed:22633490,; Belongs to the ATP-dependent AMP-binding enzyme family.

Synonyms:  ACSL4,  ACSL4p,  hACSL4,  A0A0C4DGB7,  D6RD96 ...

Linkouts:  STRING  Pharos  UniProt  OMIM

0 1 2 3 4 5 Confidence