TISSUES

Tissue expression database

BACE2 tissues

BACE2 [ENSP00000332979]

Beta-secretase 2; Responsible for the proteolytic processing of the amyloid precursor protein (APP). Cleaves APP, between residues 690 and 691, leading to the generation and extracellular release of beta-cleaved soluble APP, and a corresponding cell-associated C-terminal fragment which is later released by gamma-secretase. It has also been shown that it can cleave APP between residues 671 and 672. Responsible also for the proteolytic processing of CLTRN in pancreatic beta cells . ECO:0000269|PubMed:11083922, ECO:0000269|PubMed:11423558, ECO:0000269|PubMed:15857888, ECO:0000269|PubMed:16816112,; Belongs to the peptidase A1 family.

Synonyms:  BACE2,  BACE2p,  hBACE2,  Q9Y5Z0,  Q9Y5Z0p ...

Linkouts:  STRING  Pharos  UniProt  OMIM

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