TISSUES

Tissue expression database

SRRM1 tissues

SRRM1 [ENSP00000326261]

Serine/arginine repetitive matrix protein 1; Part of pre- and post-splicing multiprotein mRNP complexes. Involved in numerous pre-mRNA processing events. Promotes constitutive and exonic splicing enhancer (ESE)-dependent splicing activation by bridging together sequence-specific (SR family proteins, SFRS4, SFRS5 and TRA2B/SFRS10) and basal snRNP (SNRP70 and SNRPA1) factors of the spliceosome. Stimulates mRNA 3'-end cleavage independently of the formation of an exon junction complex. Binds both pre-mRNA and spliced mRNA 20-25 nt upstream of exon-exon junctions. Binds RNA and DNA with low sequence specificity and has similar preference for either double- or single-stranded nucleic acid substrates. ECO:0000269|PubMed:11739730, ECO:0000269|PubMed:12600940,

Synonyms:  SRRM1,  SRRM1p,  hSRRM1,  A0A0S2Z4W1,  A9Z1X7 ...

Linkouts:  STRING  Pharos  UniProt  OMIM

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