TISSUES

Tissue expression database

DTX2 tissues

DTX2 [ENSP00000322885]

Probable E3 ubiquitin-protein ligase DTX2; Regulator of Notch signaling, a signaling pathway involved in cell-cell communications that regulates a broad spectrum of cell-fate determinations. Probably acts both as a positive and negative regulator of Notch, depending on the developmental and cell context. Mediates the antineural activity of Notch, possibly by inhibiting the transcriptional activation mediated by MATCH1. Functions as a ubiquitin ligase protein in vitro, suggesting that it may regulate the Notch pathway via some ubiquitin ligase activity; Belongs to the Deltex family.

Synonyms:  DTX2,  DTX2p,  hDTX2,  C9IYX1,  C9JEH4 ...

Linkouts:  STRING  Pharos  UniProt  OMIM

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