TISSUES

Tissue expression database

DEF6 tissues

DEF6 [ENSP00000319831]

Differentially expressed in FDCP 6 homolog; Phosphatidylinositol 3,4,5-trisphosphate-dependent guanine nucleotide exchange factor (GEF) which plays a role in the activation of Rho GTPases RAC1, RhoA and CDC42. Can regulate cell morphology in cooperation with activated RAC1. Plays a role in Th2 (T helper cells) development and/or activation, perhaps by interfering with ZAP70 signaling (By similarity).

Synonyms:  DEF6,  DEF6p,  hDEF6,  H0Y7V7,  Q9H4E7 ...

Linkouts:  STRING  Pharos  UniProt  OMIM

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