TISSUES

Tissue expression database

ARHGEF4 tissues

ARHGEF4 [ENSP00000316845]

Rho guanine nucleotide exchange factor 4; Acts as guanine nucleotide exchange factor (GEF) for RHOA, RAC1 and CDC42 GTPases. Binding of APC may activate RAC1 GEF activity. The APC-ARHGEF4 complex seems to be involved in cell migration as well as in E-cadherin-mediated cell-cell adhesion. Required for MMP9 up- regulation via the JNK signaling pathway in colorectal tumor cells. Involved in tumor angiogenesis and may play a role in intestinal adenoma formation and tumor progression. ECO:0000269|PubMed:12598901, ECO:0000269|PubMed:17145773,

Synonyms:  ARHGEF4,  ARHGEF4p,  hARHGEF4,  A0A087X0P1,  A0A0C4DFY6 ...

Linkouts:  STRING  Pharos  UniProt  OMIM

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