TISSUES

Tissue expression database

RANBP10 tissues

RANBP10 [ENSP00000316589]

Ran-binding protein 10; May act as an adapter protein to couple membrane receptors to intracellular signaling pathways (Probable). Core component of the CTLH E3 ubiquitin-protein ligase complex that selectively accepts ubiquitin from UBE2H and mediates ubiquitination and subsequent proteasomal degradation of the transcription factor HBP1 . Enhances dihydrotestosterone-induced transactivation activity of AR, as well as dexamethasone-induced transactivation activity of NR3C1, but does not affect estrogen-induced transactivation . Acts as a guanine nucleotide exchange factor (GEF) for RAN GTPase. May play an essential role in hemostasis and in maintaining microtubule dynamics with respect to both platelet shape and function (By similarity); Belongs to the RANBP9/10 family.

Synonyms:  RANBP10,  RANBP10p,  hRANBP10,  A0A0D9SEU5,  Q6VN20 ...

Linkouts:  STRING  Pharos  UniProt  OMIM

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