TISSUES

Tissue expression database

CD320 tissues

CD320 [ENSP00000301458]

CD320 antigen; Receptor for transcobalamin saturated with cobalamin (TCbl) . Plays an important role in cobalamin uptake . Plasma membrane protein that is expressed on follicular dendritic cells (FDC) and mediates interaction with germinal center B cells . Functions as costimulator to promote B cell responses to antigenic stimuli; promotes B cell differentiation and proliferation (PubMed:10727470, PubMed:11418631). Germinal center-B (GC-B) cells differentiate into memory B-cells and plasma cells (PC) through interaction with T-cells and follicular dendritic cells (FDC) . CD320 augments the proliferation of PC precursors generated by IL-10 . ECO:0000269|PubMed:11418631, ECO:0000269|PubMed:18779389,

Synonyms:  CD320,  CD320p,  hCD320,  M0R100,  M0R1C4 ...

Linkouts:  STRING  Pharos  UniProt  OMIM

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