TISSUES

Tissue expression database

ACER1 tissues

ACER1 [ENSP00000301452]

Alkaline ceramidase 1; Endoplasmic reticulum ceramidase that catalyzes the hydrolysis of ceramides into sphingosine and free fatty acids at alkaline pH . Ceramides, sphingosine, and its phosphorylated form sphingosine-1- phosphate are bioactive lipids that mediate cellular signaling pathways regulating several biological processes including cell proliferation, apoptosis and differentiation . Exhibits a strong substrate specificity towards the natural stereoisomer of ceramides with D-erythro-sphingosine as a backbone and has a higher activity towards very long-chain unsaturated fatty acids like the C24:1-ceramide . May also hydrolyze dihydroceramides to produce dihydrosphingosine . ACER1 is a skin-specific ceramidase that regulates the levels of ceramides, sphingosine and sphingosine-1-phosphate in the epidermis, mediates the calcium-induced differentiation of epidermal keratinocytes and more generally plays an important role in skin homeostasis . ECO:0000269|PubMed:20207939, ECO:0000269|PubMed:20628055,

Synonyms:  ACER1,  ACER1p,  hACER1,  Q8TDN7,  Q8TDN7p ...

Linkouts:  STRING  Pharos  UniProt  OMIM

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