TISSUES

Tissue expression database

WAPL tissues

WAPL [ENSP00000298767]

Wings apart-like protein homolog; Regulator of sister chromatid cohesion in mitosis which negatively regulates cohesin association with chromatin. Involved in both sister chromatid cohesion during interphase and sister-chromatid resolution during early stages of mitosis. Couples DNA replication to sister chromatid cohesion. Cohesion ensures that chromosome partitioning is accurate in both meiotic and mitotic cells and plays an important role in DNA repair. ECO:0000269|PubMed:17112726, ECO:0000269|PubMed:17113138, ECO:0000269|PubMed:19696148, ECO:0000269|PubMed:19907496,; Belongs to the WAPL family.

Synonyms:  WAPL,  F6QZY1,  Q7Z5K2,  Q8WVX6,  F6QZY1p ...

Linkouts:  STRING  Pharos  UniProt  OMIM

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