WDR24 tissues
WDR24 [ENSP00000293883]
GATOR complex protein WDR24; As a component of the GATOR subcomplex GATOR2, functions within the amino acid-sensing branch of the TORC1 signaling pathway . Indirectly activates mTORC1 and the TORC1 signaling pathway through the inhibition of the GATOR1 subcomplex . It is negatively regulated by the upstream amino acid sensors SESN2 and CASTOR1 (PubMed:26449471, PubMed:26586190, PubMed:27487210). In addition to its role in regulation of the TORC1 complex, promotes the acidification of lysosomes and facilitates autophagic flux . ECO:0000269|PubMed:26449471, ECO:0000269|PubMed:26586190,; Belongs to the WD repeat WDR24 family.
Synonyms: WDR24, WDR24p, hWDR24, A0A3B3ISA1, A0A499FJD3 ...