TISSUES

Tissue expression database

ALKBH4 tissues

ALKBH4 [ENSP00000292566]

Alpha-ketoglutarate-dependent dioxygenase alkB homolog 4; Dioxygenase that mediates demethylation of actin monomethylated at 'Lys-84' (K84me1), thereby acting as a regulator of actomyosin-processes . Demethylation of actin K84me1 is required for maintaining actomyosin dynamics supporting normal cleavage furrow ingression during cytokinesis and cell migration . In addition to proteins, also demethylates DNA: specifically demethylates DNA methylated on the 6th position of adenine (N(6)-methyladenosine) DNA, thereby regulating Polycomb silencing (By similarity).

Synonyms:  ALKBH4,  ALKBH4p,  hALKBH4,  Q9NXW9,  Q9NXW9p ...

Linkouts:  STRING  Pharos  UniProt  OMIM

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