TISSUES

Tissue expression database

PDCD4 tissues

PDCD4 [ENSP00000280154]

Programmed cell death protein 4; Inhibits translation initiation and cap-dependent translation. May excert its function by hindering the interaction between EIF4A1 and EIF4G. Inhibits the helicase activity of EIF4A. Modulates the activation of JUN kinase. Down-regulates the expression of MAP4K1, thus inhibiting events important in driving invasion, namely, MAPK85 activation and consequent JUN-dependent transcription. May play a role in apoptosis. Tumor suppressor. Inhibits tumor promoter-induced neoplastic transformation. Binds RNA (By similarity). ECO:0000269|PubMed:17053147, ECO:0000269|PubMed:18296639,; Belongs to the PDCD4 family.

Synonyms:  PDCD4,  PDCD4p,  hPDCD4,  Q53EL6,  Q5VZS7 ...

Linkouts:  STRING  Pharos  UniProt  OMIM

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