MFHAS1 tissues
MFHAS1 [ENSP00000276282]
Malignant fibrous histiocytoma-amplified sequence 1; Probable GTP-binding protein . Functions in innate immunity and more specifically the inflammatory response as a regulator of the Toll-like receptor TLR2 and TLR4 signaling pathways . Negatively regulates the part of the TLR4 signaling pathway that leads to the activation of the transcription factor AP-1. By retaining the phosphatase complex PP2A into the cytoplasm, prevents the dephosphorylation of the AP-1 subunit JUN which is required for proper activation of the transcription factor . Both inhibits and activates the TLR2-dependent signaling pathway . Positively regulates the TLR2 signaling pathway to activate specifically the downstream p38 and JNK MAP kinases and promote the polarization of macrophages toward the pro-inflammatory M1 phenotype . It may also play a role in the regulation of inflammation induced by high glucose through the PKB/AKT signaling pathway . Also involved in erythrocyte differentiation through activation of the ERK1/ERK2 signaling pathway . ECO:0000269|PubMed:24286120, ECO:0000269|PubMed:26599367, ECO:0000269|PubMed:28471450, ECO:0000269|PubMed:28609714,
Synonyms: MFHAS1, MFHAS1p, hMFHAS1, Q9Y4C4, Q9Y4C4p ...