APH1B tissues
APH1B [ENSP00000261879]
Gamma-secretase subunit APH-1B; Probable subunit of the gamma-secretase complex, an endoprotease complex that catalyzes the intramembrane cleavage of integral proteins such as Notch receptors and APP (amyloid-beta precursor protein). It probably represents a stabilizing cofactor for the presenilin homodimer that promotes the formation of a stable complex. Probably present in a minority of gamma-secretase complexes compared to APH1A; Belongs to the APH-1 family.
Synonyms: APH1B, APH1Bp, hAPH1B, H0YKZ9, H0YLT0 ...