TISSUES

Tissue expression database

SLX1A tissues

SLX1A [ENSP00000251303]

Structure-specific endonuclease subunit SLX1; Catalytic subunit of the SLX1-SLX4 structure-specific endonuclease that resolves DNA secondary structures generated during DNA repair and recombination. Has endonuclease activity towards branched DNA substrates, introducing single-strand cuts in duplex DNA close to junctions with ss-DNA. Has a preference for 5'-flap structures, and promotes symmetrical cleavage of static and migrating Holliday junctions (HJs). Resolves HJs by generating two pairs of ligatable, nicked duplex products. ECO:0000269|PubMed:19595721, ECO:0000269|PubMed:19596235,

Synonyms:  SLX1A,  SLX1Ap,  hSLX1A,  H3BPC3,  Q9BQ83 ...

Linkouts:  STRING  Pharos  UniProt

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