TISSUES

Tissue expression database

QTRT1 tissues

QTRT1 [ENSP00000250237]

Queuine tRNA-ribosyltransferase catalytic subunit 1; Catalytic subunit of the queuine tRNA-ribosyltransferase (TGT) that catalyzes the base-exchange of a guanine (G) residue with queuine (Q) at position 34 (anticodon wobble position) in tRNAs with GU(N) anticodons (tRNA-Asp, -Asn, -His and -Tyr), resulting in the hypermodified nucleoside queuosine (7-(((4,5-cis-dihydroxy-2- cyclopenten-1-yl)amino)methyl)-7-deazaguanosine) (PubMed:11255023, PubMed:20354154). Catalysis occurs through a double-displacement mechanism. The nucleophile active site attacks the C1' of nucleotide 34 to detach the guanine base from the RNA, forming a covalent enzyme-RNA intermediate. The proton acceptor active site deprotonates the incoming queuine, allowing a nucleophilic attack on the C1' of the ribose to form the product (By similarity). ECO:0000255|HAMAP-Rule:MF_03218, ECO:0000269|PubMed:11255023,

Synonyms:  QTRT1,  QTRT1p,  hQTRT1,  K7EJ21,  K7EL95 ...

Linkouts:  STRING  Pharos  UniProt  OMIM

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