TISSUES

Tissue expression database

RPN2 tissues

RPN2 [ENSP00000237530]

Dolichyl-diphosphooligosaccharide--protein glycosyltransferase subunit 2; Subunit of the oligosaccharyl transferase (OST) complex that catalyzes the initial transfer of a defined glycan (Glc(3)Man(9)GlcNAc(2) in eukaryotes) from the lipid carrier dolichol- pyrophosphate to an asparagine residue within an Asn-X-Ser/Thr consensus motif in nascent polypeptide chains, the first step in protein N-glycosylation. N-glycosylation occurs cotranslationally and the complex associates with the Sec61 complex at the channel-forming translocon complex that mediates protein translocation across the endoplasmic reticulum (ER). All subunits are required for a maximal enzyme activity; Belongs to the SWP1 family.

Synonyms:  RPN2,  RPN2p,  hRPN2,  F2Z3K5,  H0Y5M1 ...

Linkouts:  STRING  Pharos  UniProt  OMIM

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