TISSUES

Tissue expression database

SNX17 tissues

SNX17 [ENSP00000233575]

Sorting nexin-17; Critical regulator of endosomal recycling of numerous surface proteins, including integrins, signaling receptor and channels . Binds to NPxY sequences in the cytoplasmic tails of target cargos . Associates with retriever and CCC complexes to prevent lysosomal degradation and promote cell surface recycling of numerous cargos such as integrins ITGB1, ITGB5 and their associated alpha subunits (PubMed:28892079, PubMed:22492727). Also required for maintenance of normal cell surface levels of APP and LRP1 . Interacts with membranes containing phosphatidylinositol 3-phosphate (PtdIns(3P)) . ECO:0000269|PubMed:15769472, ECO:0000269|PubMed:16712798, ECO:0000269|PubMed:19005208, ECO:0000269|PubMed:21512128,

Synonyms:  SNX17,  SNX17p,  hSNX17,  F8WAZ0,  F8WEG6 ...

Linkouts:  STRING  Pharos  UniProt  OMIM

0 1 2 3 4 5 Confidence