TISSUES

Tissue expression database

ZW10 tissues

ZW10 [ENSP00000200135]

Centromere/kinetochore protein zw10 homolog; Essential component of the mitotic checkpoint, which prevents cells from prematurely exiting mitosis. Required for the assembly of the dynein-dynactin and MAD1-MAD2 complexes onto kinetochores. Its function related to the spindle assembly machinery is proposed to depend on its association in the mitotic RZZ complex (PubMed:11590237, PubMed:15485811, PubMed:15824131). Involved in regulation of membrane traffic between the Golgi and the endoplasmic reticulum (ER); the function is proposed to depend on its association in the interphase NRZ complex which is believed to play a role in SNARE assembly at the ER . ECO:0000269|PubMed:15029241, ECO:0000269|PubMed:15094189,; Belongs to the ZW10 family.

Synonyms:  ZW10,  ZW10p,  hZW10,  F5H3C1,  O43264 ...

Linkouts:  STRING  Pharos  UniProt  OMIM

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