TISSUES

Tissue expression database

FAM89B tissues

FAM89B [ENSP00000431459]

Leucine repeat adapter protein 25; Negatively regulates TGF-beta-induced signaling; in cooperation with SKI prevents the translocation of SMAD2 from the nucleus to the cytoplasm in response to TGF-beta. Acts as an adapter that mediates the specific recognition of LIMK1 by CDC42BPA and CDC42BPB in the lamellipodia. LRAP25-mediated CDC42BPA/CDC42BPB targeting to LIMK1 and the lamellipodium results in LIMK1 activation and the subsequent phosphorylation of CFL1 which is important for lamellipodial F-actin regulation; Belongs to the FAM89 family.

Synonyms:  FAM89B,  FAM89Bp,  hFAM89B,  Q8N5H3,  Q8N5H3p ...

Linkouts:  STRING  Pharos  UniProt

0 1 2 3 4 5 Confidence