TISSUES

Tissue expression database

HPF1 tissues

HPF1 [ENSP00000406598]

Histone PARylation factor 1; Acts as a cofactor for serine ADP-ribosylation by conferring serine specificity on PARP1 and PARP2: interacts with PARP1 and PARP2 and is able to change amino acid specificity toward serine . Promotes histone serine ADP- ribosylation in response to DNA damage, limiting DNA damage-induced PARP1 hyper-automodification, and ensuring genome stability . Serine ADP-ribosylation of proteins constitutes the primary form of ADP-ribosylation of proteins in response to DNA damage . HPF1 also promotes tyrosine ADP-ribosylation, probably by conferring tyrosine specificity on PARP1 . ECO:0000269|PubMed:28190768, ECO:0000269|PubMed:29480802,

Synonyms:  HPF1,  HPF1p,  hHPF1,  Q9NWY4,  Q9NWY4p ...

Linkouts:  STRING  Pharos  UniProt

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