TISSUES

Tissue expression database

RHOA tissues

RHOA [ENSP00000400175]

Transforming protein RhoA; Small GTPase which cycles between an active GTP-bound and an inactive GDP-bound state. Mainly associated with cytoskeleton organization, in active state binds to a variety of effector proteins to regulate cellular responses such cytoskeletal dynamics, cell migration and cell cycle. Regulates a signal transduction pathway linking plasma membrane receptors to the assembly of focal adhesions and actin stress fibers . Involved in a microtubule-dependent signal that is required for the myosin contractile ring formation during cell cycle cytokinesis . Plays an essential role in cleavage furrow formation. Required for the apical junction formation of keratinocyte cell-cell adhesion . Essential for the SPATA13-mediated regulation of cell migration and adhesion assembly and disassembly . The MEMO1-RHOA- DIAPH1 signaling pathway plays an important role in ERBB2-dependent stabilization of microtubules at the cell cortex. It controls the localization of APC and CLASP2 to the cell membrane, via the regulation of GSK3B activity. In turn, membrane-bound APC allows the localization of the MACF1 to the cell membrane, which is required for microtubule capture and stabilization . Regulates KCNA2 potassium channel activity by reducing its location at the cell surface in response to CHRM1 activation; promotes KCNA2 endocytosis . May be an activator of PLCE1 . In neurons, involved in the inhibiton of the initial spine growth. Upon activation by CaMKII, modulates dendritic spine structural plasticity by relaying CaMKII transient activation to synapse-specific, long-term signaling (By similarity). ECO:0000269|PubMed:16103226, ECO:0000269|PubMed:16236794, ECO:0000269|PubMed:19403695, ECO:0000269|PubMed:19934221, ECO:0000269|PubMed:20937854, ECO:0000269|PubMed:20974804, ECO:0000269|PubMed:23940119, ECO:0000269|PubMed:8910519,

Synonyms:  RHOA,  A0A024R324,  C9JNR4,  C9JRM1,  C9JX21 ...

Linkouts:  STRING  Pharos  UniProt  OMIM

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