TISSUES

Tissue expression database

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MORC3 tissues

MORC3 [ENSP00000383333]

MORC family CW-type zinc finger protein 3; Nuclear factor which forms MORC3-NBs (nuclear bodies) via an ATP-dependent mechanism . Sumoylated MORC3-NBs can also associate with PML-NBs . Recruits TP53 and SP100 to PML-NBs, thus regulating TP53 activity . Binds RNA in vitro . May be required for influenza A transcription during viral infection .

Synonyms:  MORC3,  MORC3p,  hMORC3,  H0YHQ4,  H0YIR5 ...

Linkouts:  STRING  Pharos  UniProt  OMIM

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The tissue associations are derived from manually curated knowledge in UniProtKB and via automatic text mining of the biomedical literature, which has not been manually verified. The confidence of each association is signified by stars, where ★★★★★ is the highest confidence and ★☆☆☆☆ is the lowest. Download files from earlier versions are archived on figshare.

Each tissue–gene association is based on a text-mining score, which is proportional to 1) the absolute number of comentionings and 2) the ratio of observed to expected comentionings (i.e. the enrichment). These scores are normalized to z-scores by comparing them to a random background. This is represented by stars, each star corresponding to two standard deviations above the mean of the background distribution.

Developed by Alberto Santos, Oana Palasca, Christian Stolte, Kalliopi Tsafou, Sune Frankild, Janos Binder, Sean O'Donoghue, Jan Gorodkin, and Lars Juhl Jensen from the Novo Nordisk Foundation Center for Protein Research, Center for non-coding RNA in Technology and Health, and the Commonwealth Scientific and Industrial Research Organisation (CSIRO).