MAP3K20 tissues
MAP3K20 [ENSP00000364361]
Mitogen-activated protein kinase kinase kinase 20; Stress-activated component of a protein kinase signal transduction cascade. Regulates the JNK and p38 pathways. Part of a signaling cascade that begins with the activation of the adrenergic receptor ADRA1B and leads to the activation of MAPK14. Pro-apoptotic. Role in regulation of S and G2 cell cycle checkpoint by direct phosphorylation of CHEK2 (PubMed:10924358, PubMed:11836244, PubMed:15342622, PubMed:21224381). Involved in limb development . ECO:0000269|PubMed:11836244, ECO:0000269|PubMed:15342622,
Synonyms: MAP3K20, MAP3K20p, hMAP3K20, C9J3F7, D4Q8H0 ...