TISSUES

Tissue expression database

PARD3 tissues

PARD3 [ENSP00000363921]

Partitioning defective 3 homolog; Adapter protein involved in asymmetrical cell division and cell polarization processes . Seems to play a central role in the formation of epithelial tight junctions . Targets the phosphatase PTEN to cell junctions (By similarity). Involved in Schwann cell peripheral myelination (By similarity). Association with PARD6B may prevent the interaction of PARD3 with F11R/JAM1, thereby preventing tight junction assembly (By similarity). The PARD6-PARD3 complex links GTP-bound Rho small GTPases to atypical protein kinase C proteins . Required for establishment of neuronal polarity and normal axon formation in cultured hippocampal neurons . ECO:0000269|PubMed:10934474, ECO:0000269|PubMed:10954424,; Belongs to the PAR3 family.

Synonyms:  PARD3,  PARD3p,  hPARD3,  B1AP52,  F5GZI3 ...

Linkouts:  STRING  Pharos  UniProt  OMIM

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