TISSUES

Tissue expression database

UBE2A tissues

UBE2A [ENSP00000360613]

Ubiquitin-conjugating enzyme E2 A; Accepts ubiquitin from the E1 complex and catalyzes its covalent attachment to other proteins. In association with the E3 enzyme BRE1 (RNF20 and/or RNF40), it plays a role in transcription regulation by catalyzing the monoubiquitination of histone H2B at 'Lys- 120' to form H2BK120ub1. H2BK120ub1 gives a specific tag for epigenetic transcriptional activation, elongation by RNA polymerase II, telomeric silencing, and is also a prerequisite for H3K4me and H3K79me formation. In vitro catalyzes 'Lys-11', as well as 'Lys-48'-linked polyubiquitination. Required for postreplication repair of UV-damaged DNA.

Synonyms:  UBE2A,  UBE2Ap,  hUBE2A,  A0A0D9SEZ6,  A0A0D9SF75 ...

Linkouts:  STRING  Pharos  UniProt  OMIM

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